منابع مشابه
Which model for propofol TCI in children.
For several years, total intravenous anesthesia (TIVA) has demonstrated many advantages that allow consideration of propofol anesthesia as an interesting alternative in pediatric anesthesia. TIVA in children requires calculation and validation of pharmacokinetic (PK) models specifically adapted to the pediatric population. Several PK models based on a 3-compartment approach have been proposed i...
متن کاملHuman physiologically based pharmacokinetic model for propofol
BACKGROUND: Propofol is widely used for both short-term anesthesia and long-term sedation. It has unusual pharmacokinetics because of its high lipid solubility. The standard approach to describing the pharmacokinetics is by a multi-compartmental model. This paper presents the first detailed human physiologically based pharmacokinetic (PBPK) model for propofol. METHODS: PKQuest, a freely distrib...
متن کاملEvaluation of the predictive performance of four pharmacokinetic models for propofol.
BACKGROUND This study has compared the predictive performance of four pharmacokinetic models, two of which are currently incorporated in commercial target-controlled infusion pumps for the administration of propofol. METHODS Arterial propofol concentrations and patient characteristic data were available from nine patients who, in a published study, had received a standardized infusion of prop...
متن کاملCross-simulation between two pharmacokinetic models for the target-controlled infusion of propofol
BACKGROUND We investigated how one pharmacokinetic (PK) model differed in prediction of plasma (C(p)) and effect-site concentration (C(eff)) using a reproducing simulation of target-controlled infusion (TCI) with another PK model of propofol. METHODS Sixty female patients were randomly assigned to TCI using Marsh PK (Group M) and TCI using Schnider PK (Group S) targeting 6.0 µg/ml of C(p) of ...
متن کاملPharmacokinetic-pharmacodynamic modeling of propofol in children.
BACKGROUND The aim of this study was to identify the best model to describe pharmacokinetics and pharmacodynamics in prepubertal children and therefore to calculate the corresponding pharmacodynamic parameters. In addition, and to confirm our method, a group of postpubertal subjects was also studied. METHODS Sixteen children (9.5 yr, range 6-12) and 13 adults (22 yr, range 13-35) were include...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 2008
ISSN: 0003-2409,1365-2044
DOI: 10.1111/j.1365-2044.2007.05419_1.x